Born in Accra, Ghana, Amoako Boafo studied at the Ghanatta College of Art and Design before moving to Vienna, Austria, to continue his formal education at the Academy of Fine Arts Vienna. His breakthrough in the international art market occurred in the late 2010s, characterized by a rapid rise in institutional and collector interest.

Boafo is best known for his vibrant, large-scale portraits that emphasize the individuality and presence of his sitters. He frequently employs a technique of applying oil paint directly with his fingers, a method he developed to achieve a specific tactile quality and depth in his depictions of skin. His compositions often feature bold, monochromatic backgrounds that contrast with the intricate patterns of the subjects' clothing.

The artist has gained significant global recognition for his contributions to contemporary figurative painting. His works have been acquired by major public and private collections, reflecting his status as a prominent figure in the contemporary art scene.