Born Chryssa Vardea-Mavromichali in Athens, Greece, the artist moved to the United States in the 1950s, where she became a central figure in the New York City art scene. She established her reputation as a trailblazer in the use of industrial materials, particularly neon tubing, to explore the intersection of urban signage and fine art.

Her practice focused on the transformation of commercial light and typography into abstract, sculptural forms. By utilizing steel, aluminum, and acrylic glass, she created complex, luminous environments that bridged the gap between Pop art and minimalism. Her work is noted for its technical precision and its engagement with the visual language of the modern city.

Chryssa maintained studios in both New York and Athens, continuing her exploration of light-based media throughout her career. Her historical significance within the Pop art movement is underscored by her inclusion in major institutional surveys, such as the 2026 exhibition at the Solomon R. Guggenheim Museum, which traces the evolution of the movement from its 1960s origins.