Born in Johannesburg, South Africa, Dada Masilo trained at the Dance Factory before continuing her studies at the Performing Arts Research and Training Studios in Brussels. Her early career was marked by a rapid rise to international prominence as she began developing a distinct choreographic language that challenged the conventions of Western classical dance.

Masilo is best known for her high-energy, physically demanding reinterpretations of canonical works such as Swan Lake, Giselle, and The Rite of Spring. Her work frequently incorporates intricate footwork and rhythmic elements derived from African dance traditions, creating a hybrid style that addresses themes of gender, identity, and social dynamics.

She has toured extensively across the globe, collaborating with international dance companies and performing at major festivals. Her work continues to be recognized for its technical rigor and its ability to bridge disparate cultural dance vocabularies.