Born in Florence, Emilio Santarelli was a prominent sculptor during the 19th century. He received his formal training in his native city, where he became a fixture of the local artistic community and developed a reputation for his technical precision in marble.

His practice focused primarily on neoclassical sculpture, including portrait busts and figurative works that reflected the aesthetic sensibilities of the period. He was deeply integrated into the Florentine art scene, contributing to the city's long-standing tradition of marble carving.

Historical records indicate that his work remains part of the cultural heritage of Florence, where he spent the entirety of his professional career. His contributions are recognized within the context of 19th-century Italian academic sculpture.