Born Baccio della Porta in Florence, the artist trained under Cosimo Rosselli before establishing his own workshop. His early career was deeply impacted by the influence of the preacher Savonarola, which led him to join the Dominican Order in 1500 and temporarily abandon his artistic practice.

After returning to painting, he became celebrated for his religious subjects, specifically the Virgin and Child with Saints, characterized by a balanced, monumental composition. His work bridged the gap between the early Renaissance and the emerging maniera moderna, utilizing soft sfumato and carefully orchestrated spatial arrangements.

Today, his legacy remains central to the study of 16th-century Florentine art. Recent institutional efforts, such as the expansion of the Uffizi Galleries, continue to highlight his contributions alongside his contemporaries, situating his work within the broader evolution of the Florentine High Renaissance.