Born in Smyrna, Seferis pursued a dual career as a diplomat and a writer. His literary breakthrough came with the publication of Strophe in 1931, which marked a shift toward modernism in Greek poetry. Throughout his life, he balanced his professional duties in the Greek diplomatic service with an prolific output of verse and prose.

His work is characterized by a deep engagement with Greek history, mythology, and the landscape of the Mediterranean. He frequently utilized themes of exile, memory, and the intersection of the ancient past with the contemporary world, often employing a sparse, precise linguistic style.

While primarily celebrated for his literary achievements, his cultural legacy remains a subject of academic and institutional interest. His influence continues to be felt in the broader context of Mediterranean studies and the preservation of Greek cultural heritage.