Born in Botshabelo, South Africa, Gerard Sekoto began his artistic career in the 1930s, gaining early recognition for his vibrant, empathetic portrayals of urban life in Johannesburg's Sophiatown and District Six. His work marked a significant departure from the prevailing landscape traditions of the time, focusing instead on the daily realities and social conditions of black South Africans.

In 1947, Sekoto moved to Paris, where he spent the remainder of his life. His medium primarily consisted of oil painting, characterized by a bold use of color and expressive, rhythmic compositions. His work evolved to incorporate modernist influences while maintaining a deep connection to his South African roots, often exploring themes of displacement, identity, and the human condition.

Sekoto's legacy continues to be central to contemporary discourse on African art. His historical works are frequently revisited in major institutional surveys, such as the 2025 exhibition A Protea Is Not a Flower at the Zeitz Museum of Contemporary Art Africa, which places his practice in dialogue with contemporary artists to examine enduring themes of exile and identity.