Born in Mons, Grisoni trained in Florence before relocating to London around 1715. He established himself within the British art scene, gaining patronage for his ability to capture historical subjects and landscapes, often reflecting the influence of his Italian academic training.

His body of work encompasses both painting and sculpture, characterized by a focus on narrative compositions and traditional portraiture. He remained active in England for several years before eventually returning to Italy, where he continued his practice in Florence.

While historical records of his later career are sparse, his work remains a subject of interest for scholars of 18th-century Anglo-Italian artistic exchange. His legacy is preserved through the surviving canvases and sculptural pieces held in various private and public collections.