Born in Cefalù, Sicily, Jacopo del Duca moved to Rome where he became a significant figure in the Mannerist architectural and sculptural landscape. He is primarily recognized for his role as an assistant to Michelangelo, contributing to the execution of complex commissions during the mid-to-late 16th century.

His professional legacy is defined by his involvement in the construction of the tomb of Pope Julius II at San Pietro in Vincoli and his subsequent modifications to Michelangelo's architectural designs for the Capitoline Hill. His work reflects the transition between the High Renaissance and the Mannerist style prevalent in Rome during his lifetime.