Born in Cape Town, South Africa, Lisa Brice developed her artistic practice against the backdrop of the country's political upheaval. She later spent significant time living and working in Trinidad, an experience that profoundly influenced her aesthetic and thematic focus on the complexities of post-colonial identity and social dynamics.

Brice is primarily recognized for her paintings, which frequently feature solitary female figures in domestic or transitional spaces. Her work often engages with art historical references, subverting traditional depictions of women by centering their agency and interiority through a distinct, often monochromatic or blue-toned palette.

Currently based in London, Brice maintains a significant presence in the contemporary art scene. Her work continues to be exhibited internationally, reflecting a sustained critical interest in her exploration of the female subject and the intersection of personal and cultural memory.