Born in Holyoke, Massachusetts, Mitch Epstein began his career in the 1970s, establishing himself as a significant figure in the development of color photography as a fine art medium. His early work often focused on the nuances of American life, leading to a prolific career that spans several decades of documentary and landscape practice.

Epstein is best known for his thematic book projects, which often combine rigorous formal composition with deep social inquiry. His work frequently explores the tension between industrial progress and the environment, as seen in his extensive series on American power plants and urban trees. He utilizes a large-format camera to capture high-detail images that emphasize the scale and permanence of his subjects.

His work is held in numerous international museum collections and has been the subject of extensive publication. His practice continues to evolve through ongoing investigations into the relationship between property, landscape, and the shifting conditions of the modern world.