Born in South Africa, Sethembile Msezane developed an interdisciplinary practice that spans photography, film, sculpture, and drawing. She gained prominence for her performative interventions in public spaces, which challenge traditional historical narratives and the lack of representation of Black women in monuments.

Her work is deeply rooted in the exploration of spirituality, politics, and the construction of history. As a member of the iQhiya collective, a network of Black women artists based in South Africa, she has contributed to a broader discourse on the visibility of marginalized bodies within both narrative and physical environments.

Msezane’s work is held in various gallery collections across South Africa and internationally. Her artistic output continues to be recognized for its focus on myth-making and the reclamation of historical space through a contemporary lens.