Born in Velletri, Italy, Virginia da Vezzo was a painter active during the early 17th century. She received her artistic training in Rome, where she developed a style influenced by the prevailing Baroque aesthetic of the period.

Her work primarily encompasses portraiture and religious subjects, characterized by a refined handling of light and form. She gained professional standing in both Rome and Paris, where she relocated following her marriage to the prominent French painter Simon Vouet.

Her historical significance has been reaffirmed by recent institutional interest, including the 2026 acquisition of her work by the Los Angeles County Museum of Art (LACMA) for its permanent collection.