Born in Velletri in 1600, Virginia Vezzi established herself as a skilled painter in Rome during the early 17th century. She gained recognition for her artistic practice before marrying the prominent French painter Simon Vouet, with whom she collaborated and lived in Paris.

Her work is characterized by the stylistic influence of the Roman Baroque, often featuring religious and mythological subjects rendered with technical precision. She remained an active figure in the artistic circles of her time until her death in 1638.

Vezzi's historical significance continues to be recognized by major institutions, as evidenced by the recent acquisition of her work by the Los Angeles County Museum of Art (LACMA) in 2026.