Born in Umlazi, South Africa, Zanele Muholi began their career as a photographer and visual activist in the early 2000s. They gained recognition for their commitment to documenting the experiences of South Africa's Black lesbian, gay, transgender, and intersex communities, providing visibility to marginalized groups.

Muholi works across photography, video, and installation to explore identity and social justice. Their practice often involves long-term projects that serve as both artistic expression and historical record, challenging societal norms regarding gender and race.

The artist has received international acclaim for their contributions to contemporary photography and human rights advocacy. Their work has been exhibited in major institutions globally, cementing their status as a significant figure in contemporary visual culture.