Born Jamie Adenuga in London, Jme rose to prominence as a central figure in the UK grime scene. He began his career as a member of the Meridian Crew and later joined the collective Roll Deep, working alongside his brother, Skepta. In 2008, he co-founded the independent label Boy Better Know, which became a foundational entity for grime artists to maintain creative and financial autonomy.

His work is characterized by a distinct, rapid-fire lyrical style and self-produced beats that define the grime aesthetic. Beyond his musical output, he is noted for his business acumen as the sole owner and director of Boy Better Know Limited, which has played a critical role in the distribution and promotion of independent British music.

Jme continues to be recognized for his historical impact on British music culture. His contributions to the grime genre are featured in the 2026 inaugural exhibition The Music is Black: A British Story at the V&A East Museum, which documents the evolution of Black British music over the past 125 years.